Network Publications
2025
Dagum P, Giovangrandi L, Levendovszky SR, Winebaum JJ, Singh T, Cho Y, Kaplan RM, Jaffee MS, Lim MM, Vandeweerd C, Iliff JJ. A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans. Nat Biomed Eng. 2025 May 27. PMID: 40425804.
Kozberg MG, Munting LP, Hanlin LH, Auger CA, van den Berg ML, Denis de Senneville B, Hirschler L, Warnking JM, Barbier EL, Farrar CT, Greenberg SM, Bacskai BJ, van Veluw SJ. Vasomotion loss precedes impaired cerebrovascular reactivity and microbleeds in cerebral amyloid angiopathy. Brain Commun. 2025 May 14; PMID: 40406166
Schipper MR, van Harten TW, Razoux-Schultz AT, Kaushik K, Hirschler L, Voigt S, Rasing I, Koemans EA, van Dort R, van der Zwet RGJ, Schriemer SE, van Zwet EW, van der Grond J, van Buchem MA, Greenberg SM, Wermer MJH, van Osch MJP, van Walderveen MAA, van Rooden S. Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy. Neuroimage Clin. Epub 2025 Apr 5. PMID: 40209571
van der Plas MC, Koemans EA, Schipper MR, Voigt S, Rasing I, van der Zwet RGJ, Kaushik K, van Dort R, Schriemer S, van Harten TW, van Zwet E, van Etten ES, van Osch MJP, Terwindt GM, van Walderveen M, Wermer MJH. One-Year Radiologic Progression in Sporadic and Hereditary Cerebral Amyloid Angiopathy. Neurology. 2025 May 13. Epub 2025 Apr 8. PMID: 40198864
El Kamouh MR, Lenck S, Lehericy S, Benveniste H, Thomas JL. Fluid and Waste Clearance in Central Nervous System Health and Diseases. Neurodegener Dis. 2025 May 7. PMID: 40334649
Alten B, Gokcal E, Warren A, van Veluw SJ, Kozberg M, Gurol ME, Viswanathan A, Greenberg SM. Cerebrospinal Fluid Beta-Amyloid Concentration and Clinical and Radiographic Manifestations of Cerebral Amyloid Angiopathy. J Am Heart Assoc. 2025 Mar 4 Epub 2025 PMID: 40028849.
van Heese EM, Gool JK, Lammers GJ, van der Werf YD, van Osch MJP, Fronczek R, Hirschler L. MRI-based surrogates of brain clearance in narcolepsy type 1. J Sleep Res. 2025 Feb 18. Epub PMID: 39965782.
Bonnar O, Eyre B, van Veluw SJ. Perivascular brain clearance as a therapeutic target in cerebral amyloid angiopathy and Alzheimer's disease. Neurotherapeutics. 2025 Jan 30 PMID: 39890534.
2024
Roefs ECA, Eiling I, de Bresser J, van Osch MJP, Hirschler L. BOLD-CSF dynamics assessed using real-time phase contrast CSF flow interleaved with cortical BOLD MRI. Fluids Barriers CNS. 2024 Dec 24;21(1):107. PMID: 39719574
Koundal S, Chen X, Gursky Z, Lee H, Xu K, Liang F, Xie Z, Xu F, Lin HM, Van Nostrand WE, Gu X, Elkin R, Tannenbaum A, Benveniste H. Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer's disease. iScience. 2024 Nov 23;27(12):111463. PMID: 39720539
Makkinejad N, Zanon Zotin MC, van den Brink H, Auger CA, Vom Eigen KA, Iglesias JE, Greenberg SM, Perosa V, van Veluw SJ. Neuropathological Correlates of White Matter Hyperintensities in Cerebral Amyloid Angiopathy. J Am Heart Assoc. 2024 Nov 19;13(22):e035744. Epub 2024 Nov 11. PMID: 39526350.
van Dort R, Kaushik K, Rasing I, van der Zwet RGJ, Schipper MR, van der Grond J, van Rooden S, van Zwet EW, Terwindt GM, Middelkoop HAM, Hart EP, van Osch MJP, van Walderveen MAA, Wermer MJH. Cognition in (pre)symptomatic Dutch-type hereditary and sporadic cerebral amyloid angiopathy. Alzheimers Dement. 2024 Nov;20(11):7518-7528. Epub 2024 Oct 10. PMID: 39387105
Schrader JM, Majchrzak M, Xu F, Lee H, Agostinucci K, Davis J, Benveniste H, Van Nostrand WE. Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments. Neurosci Insights. 2024 Oct 8;19:26331055241288172. PMID: 39386146
van den Berg E, Roelofs R, Jäkel L, Greenberg SM, Charidimou A, van Etten ES, Boche D, Klijn CJM, Schreuder FHBM, Kuiperij HB, Verbeek MM. No replicating evidence for anti-amyloid-β autoantibodies in cerebral amyloid angiopathy-related inflammation. Ann Clin Transl Neurol. 2024 Oct;11(10):2563-2571. Epub 2024 Sep 13. PMID: 39268830
Bonney SK, Nielson CD, Sosa MJ, Bonnar O, Shih AY. Capillary regression leads to sustained local hypoperfusion by inducing constriction of upstream transitional vessels. Proc Natl Acad Sci U S A. 2024 Sep 10;121(37):e2321021121 Epub 2024 Sep 5. PMID: 39236241.
Liu H, Chen L, Zhang C, Liu C, Li Y, Cheng L, Ouyang Y, Rutledge C, Anderson J, Wei Z, Zhang Z, Lu H, Van Zijl PC, Iliff JJ, Xu J, Duan W. Glymphatic influx and clearance are perturbed in Huntington's disease. JCI Insight. 2024 Sep 3:e172286. PMID: 39226105.
Preis L, Villringer K, Brosseron F, Düzel E, Jessen F, Petzold GC, Ramirez A, Spottke A, Fiebach JB, Peters O. Assessing blood-brain barrier dysfunction and its association with Alzheimer's pathology, cognitive impairment and neuroinflammation. Alzheimers Res Ther. 2024 Jul 31;16(1):172. PMID: 39085945
Smets NG, van der Panne SA, Strijkers GJ, Bakker ENTP. Perivascular spaces around arteries exceed perivenous spaces in the mouse brain. Sci Rep. 2024 Jul 26;14(1):17655. PMID: 39085283
Abdennadher M, Jacobellis S, Václavů L, Juttukonda M, Inati S, Goldstein L, van Osch MJP, Rosen B, Hua N, Theodore W. Water exchange across the blood-brain barrier and epilepsy: Review on pathophysiology and neuroimaging. Epilepsia Open. 2024 Aug;9(4):1123-1135. Epub 2024 Jun 17. PMID: 38884502
Koemans EA, van Harten TW, Voigt S, Rasing I, van Zwet EW, Terwindt GM, van Osch MJP, van Walderveen MAA, Wermer MJH. One size does not fit all: micro- meso and macrobleeds in cerebral amyloid angiopathy. Cerebrovasc Dis. 2024 Aug 19. PMID: 39159610
Oliveira ÍAF, Schnabel R, van Osch MJP, Zwaag WV, Hirschler L. Advancing 7T perfusion imaging by pulsed arterial spin labeling: Using a parallel transmit coil for enhanced labeling robustness and temporal SNR. PLoS One. 2024 Aug 26;19(8):e0309204. PMID: 39186519
Liu P, Lin Z, Hazel K, Pottanat G, Xu C, Jiang D, Pillai JJ, Lucke E, Bauer CE, Gold BT, Greenberg SM, Helmer KG, Jann K, Jicha G, Kramer J, Maillard P, Mulavelil RM, Rodriguez P, Satizabal CL, Schwab K, Seshadri S, Singh H, Velarde Dediós ÁG, Wang DJJ, Kalyani RR, Moghekar A, Rosenberg PB, Yasar S, Albert M, Lu H. Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease-related cognitive decline: Multi-site validation in the MarkVCID Consortium. Alzheimers Dement. 2024 Aug;20(8):5281-5289. PMID: 38951718
Rasing I, Jellema L, Voigt S, Kaushik K, Koemans EA, van Zwet EW, van Etten ES, Greenberg SM, van Walderveen MAA, Terwindt GM, Wermer MJH. Parental influence on intracerebral hemorrhage onset in hereditary Dutch-type cerebral amyloid angiopathy. Cerebrovasc Dis. 2024 Jun 27. PMID: 38952109.
Oltmer J, Mattern H, Beck J, Yakupov R, Greenberg SM, Zwanenburg JJ, Arts T, Düzel E, van Veluw SJ, Schreiber S, Perosa V. Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins. J Cereb Blood Flow Metab. 2024 Jun 11:271678X241260629. PMID: 38863151.
Braun M, Sevao M, Keil SA, Gino E, Wang MX, Lee J, Haveliwala MA, Klein E, Agarwal S, Pedersen T, Rhodes CH, Jansson D, Cook D, Peskind E, Perl DP, Piantino J, Schindler AG, Iliff JJ. Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function. Brain. 2024 Jun 3;147(6):2214-2229. PMID: 38802114.
Fu Z, Crooks EJ, Irizarry BA, Zhu X, Chowdhury S, Van Nostrand WE, Smith SO. An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy. J Struct Biol. 2024 Jun;216(2):108092. PMID: 38615725.
van Veluw SJ, Benveniste H, Bakker ENTP, Carare RO, Greenberg SM, Iliff JJ, Lorthois S, Van Nostrand WE, Petzold GC, Shih AY, van Osch MJP. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cell Mol Life Sci. 2024 May 27;81(1):239. PMID: 38801464.
Pastor-Alonso D, Berg M, Boyer F, Fomin-Thunemann N, Quintard M, Davit Y, Lorthois S. Modeling oxygen transport in the brain: An efficient coarse-grid approach to capture perivascular gradients in the parenchyma. PLoS Comput Biol. 2024 May 23;20(5):e1011973. PMID: 38781253.
Broggini T, Duckworth J, Ji X, Liu R, Xia X, Mächler P, Shaked I, Munting LP, Iyengar S, Kotlikoff M, van Veluw SJ, Vergassola M, Mishne G, Kleinfeld D. Long-wavelength traveling waves of vasomotion modulate the perfusion of cortex. Neuron. 2024 May 17:S0896-6273(24)00324-6. PMID: 38781972.
Greenberg SM, van Veluw SJ. Cerebral Amyloid Angiopathy. Stroke. 2024 May;55(5):1409-1411. PMID: 38269538.
Rasing I, Voigt S, Koemans EA, de Kort AM, van Harten TW, van Etten ES, van Zwet EW, Stoops E, Francois C, Kuiperij BH, Klijn CJM, Schreuder FHBM, van der Weerd L, van Osch MJP, van Walderveen MAA, Verbeek MM, Terwindt GM, Wermer MJH. Serum and cerebrospinal fluid neurofilament light chain and glial fibrillary acid protein levels in early and advanced stages of cerebral amyloid Angiopathy. Alzheimers Res Ther. 2024 Apr 23;16(1):86. PMID: 38654326.
Deike K, Decker A, Scheyhing P, Harten J, Zimmermann N, Paech D, Peters O, Freiesleben SD, Schneider LS, Preis L, Priller J, Spruth E, Altenstein S, Lohse A, Fliessbach K, Kimmich O, Wiltfang J, Bartels C, Hansen N, Jessen F, Rostamzadeh A, Düzel E, Glanz W, Incesoy EI, Butryn M, Buerger K, Janowitz D, Ewers M, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Goerss D, Laske C, Munk MH, Spottke A, Roy N, Wagner M, Roeske S, Heneka MT, Brosseron F, Ramirez A, Dobisch L, Wolfsgruber S, Kleineidam L, Yakupov R, Stark M, Schmid MC, Berger M, Hetzer S, Dechent P, Scheffler K, Petzold GC, Schneider A, Effland A, Radbruch A. Machine Learning-Based Perivascular Space Volumetry in Alzheimer Disease. Invest Radiol. 2024 Apr 23. PMID: 38652067.
van Osch MJP, Wåhlin A, Scheyhing P, Mossige I, Hirschler L, Eklund A, Mogensen K, Gomolka R, Radbruch A, Qvarlander S, Decker A, Nedergaard M, Mori Y, Eide PK, Deike K, Ringstad G. Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood. NMR Biomed. 2024 Apr 18:e5159. PMID: 38634301.
Fu Z, Crooks EJ, Irizarry BA, Zhu X, Chowdhury S, Van Nostrand WE, Smith SO. An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy. J Struct Biol. 2024 Apr 13;216(2):108092. PMID: 38615725.
Schrader JM, Xu F, Agostinucci KJ, DaSilva NA, Van Nostrand WE. Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats. Sci Rep. 2024 Apr 10;14(1):8441. PMID: 38600214.
van der Zwet R, Koemans EA, Voigt S, van Dort R, Rasing I, Kaushik K, van Harten TW, Schipper MR, Terwindt GM, van Osch M, van Walderveen M, van Etten ES, Wermer M. Sensitivity of the Boston criteria version 2.0 in Dutch-type hereditary cerebral amyloid angiopathy. Int J Stroke. 2024 Mar 21:17474930241239801. PMID: 38444323.
Koemans EA, Rasing I, Voigt S, van Harten TW, van der Zwet RGJ, Kaushik K, Schipper MR, van der Weerd N, van Zwet EW, van Etten ES, van Osch MJP, Kuiperij B, Verbeek MM, Terwindt GM, Greenberg SM, van Walderveen MAA, Wermer MJH. Temporal Ordering of Biomarkers in Dutch-Type Hereditary Cerebral Amyloid Angiopathy. Stroke. 2024 Apr;55(4):954-962 Epub 2024 Mar 6. PMID: 38445479.
Boisserand LSB, Geraldo LH, Bouchart J, El Kamouh MR, Lee S, Sanganahalli BG, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Saceanu Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez SE, Singhabahu R, Robinson ME, Askenase MH, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing LH, Benveniste H, Hyder F, Thomas JL. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. J Exp Med. 2024 Apr 1;221(4):e20221983 Epub 2024 Mar 5. PMID: 38442272.
Richmond SB, Seidler RD, Iliff JJ, Schwartz DL, Luther M, Silbert LC, Wood SJ, Bloomberg JJ, Mulder E, Lee JK, De Luca A, Piantino J. Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest. NPJ Microgravity. 2024 Mar 1;10(1):24. PMID: 38429289.
Licastro E, Pignataro G, Iliff JJ, Xiang Y, Lo EH, Hayakawa K, Esposito E. Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system. Commun Biol. 2024 Feb 24;7(1):229. PMID: 38402351.
Bax F, Warren A, Fouks AA, van den Brink H, van Veluw SJ, Kozberg MG, Greenberg SM. Minocycline in Severe Cerebral Amyloid Angiopathy: A Single-Center Cohort Study. J Am Heart Assoc. 2024 Feb 20;13(4):e033464. PMID: 38348811.
Sohrabi HR, Greenberg SM, Whiley L. Editorial: Cerebral amyloid angiopathy: from bench to bedside. Front Neurosci. 2024 Feb 6;18:1370352. PMID: 38379758.
Agarwal N, Lewis LD, Hirschler L, Rivera LR, Naganawa S, Levendovszky SR, Ringstad G, Klarica M, Wardlaw J, Iadecola C, Hawkes C, Carare RO, Wells J, Bakker ENTP, Kurtcuoglu V, Bilston L, Nedergaard M, Mori Y, Stoodley M, Alperin N, de Leon M, van Osch MJP. Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome. J Magn Reson Imaging. 2024 Feb;59(2):431-449. PMID: 37141288.
van Veluw SJ, Benveniste H, van Osch MJP; Leducq Foundation Transatlantic Network of Excellence on Brain Clearance. A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy. Eur Heart J. 2024 Jan 30:ehae011. PMID: 38289319.
Savar SM, Ma B, Hone E, Jahan F, Markovic S, Pedrini S, Shemehsavar S, Easwaran V, Taddei K, Gardener S, Chhatwal JP, van Etten ES, van Osch MJP, Clarke D, Gnjec A, van Buchem MA, Wermer MJH, Hankey GJ, Greenberg SM, Martins RN, Sohrabi HR. Fluid biomarkers in cerebral amyloid angiopathy. Front Neurosci. 2024 Jan 26;18:1347320. PMID: 38344467.
Perosa V, Zanon Zotin MC, Schoemaker D, Sveikata L, Etherton MR, Charidimou A, Greenberg SM, Viswanathan A. Association Between Hippocampal Volumes and Cognition in Cerebral Amyloid Angiopathy. Neurology. 2024 Jan 23;102(2):e207854. PMID: 38165326.
Yamamoto EA, Koike S, Luther M, Dennis L, Lim MM, Raskind M, Pagulayan K, Iliff J, Peskind E, Piantino JA. Perivascular Space Burden and Cerebrospinal Fluid Biomarkers in US Veterans With Blast-Related Mild Traumatic Brain Injury. J Neurotrauma. 2024 Jan 19. PMID: 38185848.
Chen X, Benveniste H, Tannenbaum AR. Unbalanced regularized optimal mass transport with applications to fluid flows in the brain. Sci Rep. 2024 Jan 11;14(1):1111. PMID: 38212659.
Zanon Zotin MC, Makkinejad N, Schneider JA, Arfanakis K, Charidimou A, Greenberg SM, van Veluw SJ. Sensitivity and Specificity of the Boston Criteria Version 2.0 for the Diagnosis of Cerebral Amyloid Angiopathy in a Community-Based Sample. Neurology. 2024 Jan 9;102(1):e207940. PMID: 38165367.
Vervuurt M, Schrader JM, de Kort AM, Kersten I, Wessels HJCT, Klijn CJM, Schreuder FHBM, Kuiperij HB, Gloerich J, Van Nostrand WE, Verbeek MM. Cerebrospinal fluid shotgun proteomics identifies distinct proteomic patterns in cerebral amyloid angiopathy rodent models and human patients. Acta Neuropathol Commun. 2024 Jan 8;12(1):6. PMID: 38191511.